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Modic type vertebral endplate changes

MedGen UID:
907826
•Concept ID:
C4280778
•
Finding
HPO: HP:0030775

Definition

An abnormal magnetic resonance tomography signal from a vertebral endplate according to a widely used classification published by Dr. Michael Modic. [from HPO]

Professional guidelines

PubMed

Basivertebral Nerve Ablation for the Treatment of Chronic Low Back Pain: A Scoping Review of the Literature.
Schnapp W, Martiatu K, Delcroix GJ
Pain Physician 2022 Jul;25(4):E551-E562. PMID: 35793179

Recent clinical studies

Etiology

The Relationship Between Modic Changes and Endplate Sclerosis in Patients with Lumbar Degenerative Disease: A Systematic Review and Network Meta-Analysis.
Duan Y, Feng D, Zou K, Yang F, Chen R, Huang Y
World Neurosurg 2024 Jun;186:7-16. Epub 2024 Mar 12 doi: 10.1016/j.wneu.2024.03.017. PMID: 38479643
Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.
Czaplewski LG, Rimmer O, McHale D, Laslett M
J Orthop Surg Res 2023 May 12;18(1):351. doi: 10.1186/s13018-023-03839-w. PMID: 37170132Free PMC Article
Endplate and Facet Joint Changes in Cervical Spondylotic Myelopathy.
ElFiky T, Bessada B, Stienen MN, Siam AE, Hasan A
World Neurosurg 2023 Jul;175:e361-e366. Epub 2023 Mar 27 doi: 10.1016/j.wneu.2023.03.096. PMID: 36990347
Modic Change: An Emerging Complication in the Aging Population.
Applebaum A, Nessim A, Cho W
Clin Spine Surg 2022 Feb 1;35(1):12-17. doi: 10.1097/BSD.0000000000001168. PMID: 33769981
Association Between Vertebral Dimensions and Lumbar Modic Changes.
Julin M, Saukkonen J, Oura P, Junno JA, Niemelä M, Määttä J, Niinimäki J, Jämsä T, Korpelainen R, Karppinen J
Spine (Phila Pa 1976) 2021 Apr 1;46(7):E415-E425. doi: 10.1097/BRS.0000000000003797. PMID: 33692323

Diagnosis

Association between vertebral endplate defects and patient-reported symptoms: an immunohistochemical study investigating the COX-2/PGE-2/EP-4 axis.
Chen H, Zhou Q, Pu X, Wang N, Wang S, Feng Z, Wang B, Zhu Z, Qiu Y, Sun X
Spine J 2024 Aug;24(8):1407-1415. Epub 2024 Apr 15 doi: 10.1016/j.spinee.2024.04.003. PMID: 38631491
Degenerative disease of the spine: How to relate clinical symptoms to radiological findings.
Sąsiadek M, Jacków-Nowicka J
Adv Clin Exp Med 2024 Jan;33(1):91-98. doi: 10.17219/acem/163357. PMID: 37549011
A definition and clinical grading of Modic changes.
Udby PM, Samartzis D, Carreon LY, Andersen MØ, Karppinen J, Modic M
J Orthop Res 2022 Feb;40(2):301-307. Epub 2021 Dec 27 doi: 10.1002/jor.25240. PMID: 34910328
Modic Change: An Emerging Complication in the Aging Population.
Applebaum A, Nessim A, Cho W
Clin Spine Surg 2022 Feb 1;35(1):12-17. doi: 10.1097/BSD.0000000000001168. PMID: 33769981
Spondylodiscitis.
Márquez Sánchez P
Radiologia 2016 Apr;58 Suppl 1:50-9. Epub 2016 Feb 9 doi: 10.1016/j.rx.2015.12.005. PMID: 26869521

Therapy

The disc-endplate-bone-marrow complex classification: progress in our understanding of Modic vertebral endplate changes and their clinical relevance.
Rajasekaran S, Bt P, Murugan C, Mengesha MG, Easwaran M, Naik AS, Ks SVA, Kanna RM, Shetty AP
Spine J 2024 Jan;24(1):34-45. Epub 2023 Sep 9 doi: 10.1016/j.spinee.2023.09.002. PMID: 37690481
Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.
Czaplewski LG, Rimmer O, McHale D, Laslett M
J Orthop Surg Res 2023 May 12;18(1):351. doi: 10.1186/s13018-023-03839-w. PMID: 37170132Free PMC Article
MRI image features with an evident relation to low back pain: a narrative review.
van der Graaf JW, Kroeze RJ, Buckens CFM, Lessmann N, van Hooff ML
Eur Spine J 2023 May;32(5):1830-1841. Epub 2023 Mar 9 doi: 10.1007/s00586-023-07602-x. PMID: 36892719
Modic Changes (MCs) Associated with Endplate Sclerosis Can Prevent Cage Subsidence in Oblique Lumbar Interbody Fusion (OLIF) Stand-Alone.
Liu J, Ding W, Yang D, Wu H, Hao L, Hu Z, Fan S, Zhao F
World Neurosurg 2020 Jun;138:e160-e168. Epub 2020 Feb 17 doi: 10.1016/j.wneu.2020.02.047. PMID: 32081816
Prevalence of vertebral endplate modic changes in degenerative lumbar scoliosis and its associated factors analysis.
Wu HL, Ding WY, Shen Y, Zhang YZ, Guo JK, Sun YP, Cao LZ
Spine (Phila Pa 1976) 2012 Nov 1;37(23):1958-64. doi: 10.1097/BRS.0b013e31825bfb85. PMID: 22565387

Prognosis

The disc-endplate-bone-marrow complex classification: progress in our understanding of Modic vertebral endplate changes and their clinical relevance.
Rajasekaran S, Bt P, Murugan C, Mengesha MG, Easwaran M, Naik AS, Ks SVA, Kanna RM, Shetty AP
Spine J 2024 Jan;24(1):34-45. Epub 2023 Sep 9 doi: 10.1016/j.spinee.2023.09.002. PMID: 37690481
Endplate abnormalities, Modic changes and their relationship to alignment parameters and surgical outcomes in the cervical spine.
Baker JD, Sayari AJ, Tao Y, Louie PK, Basques BA, Galbusera F, Niemeyer F, Wilke HJ, An HS, Samartzis D
J Orthop Res 2023 Jan;41(1):206-214. Epub 2022 Apr 10 doi: 10.1002/jor.25333. PMID: 35398932
Apparent diffusion coefficient values in Modic changes - interobserver reproducibility and relation to Modic type.
Dagestad MH, Vetti N, Kristoffersen PM, Zwart JA, Storheim K, Bakland G, Brox JI, Grøvle L, Marchand GH, Andersen E, Assmus J, Espeland A
BMC Musculoskelet Disord 2022 Jul 22;23(1):695. doi: 10.1186/s12891-022-05610-4. PMID: 35869480Free PMC Article
The course of Modic vertebral body changes after posterolateral lumbar fusion on fused and adjacent levels: A systematic review of the literature.
Portella ST, Acioly MA
J Clin Neurosci 2017 Jul;41:6-10. Epub 2017 Apr 19 doi: 10.1016/j.jocn.2017.04.007. PMID: 28431955
Spondylodiscitis.
Márquez Sánchez P
Radiologia 2016 Apr;58 Suppl 1:50-9. Epub 2016 Feb 9 doi: 10.1016/j.rx.2015.12.005. PMID: 26869521

Clinical prediction guides

Association between vertebral endplate defects and patient-reported symptoms: an immunohistochemical study investigating the COX-2/PGE-2/EP-4 axis.
Chen H, Zhou Q, Pu X, Wang N, Wang S, Feng Z, Wang B, Zhu Z, Qiu Y, Sun X
Spine J 2024 Aug;24(8):1407-1415. Epub 2024 Apr 15 doi: 10.1016/j.spinee.2024.04.003. PMID: 38631491
Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.
Czaplewski LG, Rimmer O, McHale D, Laslett M
J Orthop Surg Res 2023 May 12;18(1):351. doi: 10.1186/s13018-023-03839-w. PMID: 37170132Free PMC Article
Endplate and Facet Joint Changes in Cervical Spondylotic Myelopathy.
ElFiky T, Bessada B, Stienen MN, Siam AE, Hasan A
World Neurosurg 2023 Jul;175:e361-e366. Epub 2023 Mar 27 doi: 10.1016/j.wneu.2023.03.096. PMID: 36990347
Apparent diffusion coefficient values in Modic changes - interobserver reproducibility and relation to Modic type.
Dagestad MH, Vetti N, Kristoffersen PM, Zwart JA, Storheim K, Bakland G, Brox JI, Grøvle L, Marchand GH, Andersen E, Assmus J, Espeland A
BMC Musculoskelet Disord 2022 Jul 22;23(1):695. doi: 10.1186/s12891-022-05610-4. PMID: 35869480Free PMC Article
A definition and clinical grading of Modic changes.
Udby PM, Samartzis D, Carreon LY, Andersen MØ, Karppinen J, Modic M
J Orthop Res 2022 Feb;40(2):301-307. Epub 2021 Dec 27 doi: 10.1002/jor.25240. PMID: 34910328

Recent systematic reviews

The Relationship Between Modic Changes and Endplate Sclerosis in Patients with Lumbar Degenerative Disease: A Systematic Review and Network Meta-Analysis.
Duan Y, Feng D, Zou K, Yang F, Chen R, Huang Y
World Neurosurg 2024 Jun;186:7-16. Epub 2024 Mar 12 doi: 10.1016/j.wneu.2024.03.017. PMID: 38479643
The Effectiveness of Intraosseous Basivertebral Nerve Radiofrequency Neurotomy for the Treatment of Chronic Low Back Pain in Patients with Modic Changes: A Systematic Review.
Conger A, Schuster NM, Cheng DS, Sperry BP, Joshi AB, Haring RS, Duszynski B, McCormick ZL
Pain Med 2021 May 21;22(5):1039-1054. doi: 10.1093/pm/pnab040. PMID: 33544851
The course of Modic vertebral body changes after posterolateral lumbar fusion on fused and adjacent levels: A systematic review of the literature.
Portella ST, Acioly MA
J Clin Neurosci 2017 Jul;41:6-10. Epub 2017 Apr 19 doi: 10.1016/j.jocn.2017.04.007. PMID: 28431955
Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain.
Jensen TS, Karppinen J, Sorensen JS, Niinimäki J, Leboeuf-Yde C
Eur Spine J 2008 Nov;17(11):1407-22. Epub 2008 Sep 12 doi: 10.1007/s00586-008-0770-2. PMID: 18787845Free PMC Article

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